Table 1.
Clinical and Germline Mutation Data in Five MEN1 Patients with 15 Smooth Muscle Tumors
| Patient no. | Age MEN1*/age leiomyoma† | Sex | Leiomyoma site (no. of tumors‡) | MEN1 germline mutation | MEN1-associated tumors |
|---|---|---|---|---|---|
| 1 | 36 /57 | F | Esophagus (1) | kdel119 | Parathyroid tumors |
| Gastrinomas | |||||
| Lipoma | |||||
| 2 | 29 /51 | F | Esophagus (2) | 512delC | Parathyroid tumors |
| Gastrinomas | |||||
| Pancreatic neuroendocrine tumors (nonfunctioning) | |||||
| Lung carcinoid | |||||
| 3 | 35 /56 | F | Uterus (3) | 1650insC | Parathyroid tumors |
| Gastrinomas | |||||
| Pancreatic neuroendocrine tumors (nonfunctioning) | |||||
| 4 | 34 /40 | F | Lung (3) | 735del4 | Parathyroid tumors |
| Esophagus (1) | |||||
| Uterus (3) | |||||
| 5 | 36 /35 | F | Esophagus (2) | 11202del2 | Parathyroid tumors |
| Gastrinomas | |||||
| Metastatic gastrinoma | |||||
| Pancreatic neuroendocrine tumors (nonfunctioning) | |||||
| Lipoma | |||||
| Angiofibromas |
*Patient’s age at time of clinical diagnosis of MEN1.
†Patient’s age at time of leiomyoma diagnosis.
‡Number of smooth muscle tumors available for LOH analysis.