Figure 2.
Immunohistochemical staining for E-Cadherin in normal bladder epithelium (A) and bladder cancers (B–D). The papillary cancer in B was scored as 2+ (1+ for intensity and 3+ for extent) and the infiltrating cancer in C was scored as 1+ (both extent and intensity). D: An infiltrating cancer with heterogeneous staining for E-Cadherin (scored as 2+ for both extent and intensity). All neoplasms (B–D) have methylation of e-cadherin.