Table 1.
Kinetics of Liver Repopulation by Transplanted ED 14 FLEP Cells versus Adult Hepatocytes in Normal Rats
| Months after cell transplantation | ||||
|---|---|---|---|---|
| 1 | 2 | 4 | 6 | |
| ED-14 fetal liver epithelial cells | ||||
| Clusters/cm2 | 1.7 | 5.0 | 15 | 82 |
| Cells/cluster | 50 | 192 | 485 | 920 |
| Divisions/cluster | 5–6 | 7–8 | 9 | 10 |
| % Repopulation | 1.4 | 1.8 | 2.4 | 6.6 |
| Adult hepatocytes | ||||
| Clusters/cm2 | 70 | 30 | — | 40 |
| Cells/cluster | 16 | 14 | — | 10 |
| Divisions/cluster | 4 | 4 | — | 3 |
| % Repopulation* | 0.6 | 0.07 | — | 0.06 |
*Due to a technical limitation of the computerized scanning method to detect very small clusters of DPPIV+ cells, the percent repopulation by adult hepatocytes is underestimated. This discrepancy is most evident at the 1-month time point; however, it does not affect the overall interpretation of the data.