Figure 1.

Expression of polyglutamine expansions results in protein aggregates in C. elegans. The localization of Q19-GFP (A) and Q82-GFP (B) expressed in body wall muscle cells in adult C. elegans detected by fluorescence microscopy. (C) Q82-GFP protein aggregates in body wall muscle cells of adults observed at high magnification (×40) reveals that the aggregates varied widely in size. (D) The cytoplasmic localization of Q82-GFP aggregates was determined by propidium iodide staining (in red) and presented as a merged image (×100).