Figure 2.
In situ hybridization localization of myosin XVA mRNA in neuroendocrine tissues. A: The anterior pituitary cells are diffusely positive (3+) for myosin XVA mRNA with the antisense probe. B: The sense probe is negative in the pituitary cell. C: A PRL-producing adenoma shows strong positive staining (3+) for myosin XVA mRNA. D: The adrenal medulla (arrows) is moderately positive (2+) for myosin XVA mRNA whereas the adjacent cortex shows some background staining. E: The pancreatic islet cells (arrows) are weakly positive (1+) for myosin XVA mRNA. F: The normal liver tissue is negative for myosin XVA mRNA. Original magnifications: ×250 (A–C, E), ×200 (D).