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. 2001 Oct;159(4):1345–1352. doi: 10.1016/S0002-9440(10)62521-7

Figure 3.

Figure 3.

Functional p53 inactivation by HPV-E6 infection in ACC-LC-176. A: Western blot analysis of p53 in HPV16-E6-infected clones. Induction of p53 in response to irradiation, which is clearly seen in the control clone (La), is abrogated in HPV16-E6-infected clones (Ea, Eb, and Ed). B: Mitotic indices of HPV16-E6-infected clones of ACC-LC-176 in the presence of nocodazole. Transient accumulation of cells at the metaphase and subsequent adaptation is seen within 32 hours regardless of the p53 status.