Table 3.
Lack of Direct Induction of CIN by HPV16-E6-Directed Inactivation of p53 in ACC-LC-176 Cells
| Infection | Clone | % with losses or gains | Instability score* | Mitotic delay | Centrosome abnormality† | |
|---|---|---|---|---|---|---|
| Ch. 11 | Ch. 12 | |||||
| LXSN | La | 6% (2)‡ | 5% (2) | 0 (0/10) | Normal | — |
| Lb | 5% (2) | 1% (2) | Normal | — | ||
| Lc | 8% (2) | 8% (2) | N.D. | — | ||
| Ld | 5% (2) | 9% (2) | N.D. | — | ||
| Le | 6% (2) | 8% (2) | N.D. | — | ||
| HPV16-E6 | Ea | 6% (2) | 3% (2) | 0.1 (1/10) | N.D. | — |
| Eb | 5% (2) | 1% (2) | Normal | — | ||
| Ec | 2% (2) | 5% (2) | N.D. | — | ||
| Ed | 12% (2) | 7% (2) | Normal | — | ||
| Ee | 4% (2) | 7% (2) | N.D. | — | ||
*Fraction of events (i.e., losses or gains compared with modal number of chromosomes) observed in the two infections.
†Determined as described in the footnote of Table 2 ▶ .
‡Numbers in parentheses show modal numbers of each chromosome.