Figure 5.

Relative tumor growth of PAC120 tumors, effects of surgical castration. PAC120 fragments were grafted into 10 male nude mice; 4 to 6 weeks after grafting, tumors appeared; when the tumor size reached 500 mm 3 (on average), the mice were surgically castrated (day 1). Individual growth curves were established. Five mice sacrificed at day 100 displayed complete regression; the five other mice survived to day 220, when they were sacrificed. Mean tumor growth in control mice is shown (filled circles).