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Individual growth curves of PAC120 established in male nude mice; effects of FE 200486 on the growth of mice. FE 200486 diluted in 5% mannitol was administered subcutaneously at a dose of 2 mg/kg, every 2 weeks. For five mice, the treatment was stopped after the fourth injection (dotted lines), or continued for five others (solid lines). The average growth control is shown (filled circles).
