Figure 8.

Histological features of hormone-independent recurrences of PAC120, the HID xenografts, at the second transplantation in castrated male (HES; original magnification, ×400). A: HID33, a microscopic pattern close to that of the hormone-dependent PAC120 tumor. B: HID19, large sheets of tumor cells, without glandular differentiation. C: HID-34, focal neuroendocrine-like pattern. D and E: HID-28 and HID-25, mixed forms composed of well-limited mucoid cell areas contiguous with areas morphologically similar to PAC120. F: HID25, a fully mucoid adenocarcinoma.