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. 2001 Dec;159(6):1987–1992. doi: 10.1016/S0002-9440(10)63049-0

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Copyright © 2001, American Society for Investigative Pathology

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Figure 1. — Histological features of t(15;19) cases 1–3. a: Case 1 is remarkable for sheets of very discohesive undifferentiated cells with scant cytoplasm and prominent, central nucleoli. The tumor was found adjacent to thymus, but as seen here also invaded bronchial seromucinous glands, and was found nearby to undermine and replace the ciliated columnar epithelium (H&E, ×400). b: Case 2 has syncitial sheets of undifferentiated cells with frequent mitoses, single cell necrosis, and percolating lymphocytes giving a lymphoepithelial-like appearance (H&E, ×600). c: Case 3 has prominent nests of undifferentiated cells with focal keratinization (H&E, ×600). Inset: dual-color FISH reveals rearrangement, as evidenced by splitting apart of red-green probe doublet, in paraffin section of this sinonasal carcinoma. d: Immunoperoxidase studies (case 2) show reactivity for pan-keratin (MNF116-alkaline phosphatase, red), indicating epithelial differentiation (hematoxylin counterstain, ×400).