Table 2.

Expression of MMP-2, MT-1-MMP, TIMP-1, TIMP-2, and Type IV Collagen in Lepidic and Invasive Areas of Pulmonary Adenocarcinomas with Bronchioloalveolar Component and Atypical Adenomatous Hyperplasia

Case	Type IV collagen		MMP-2		MT-1-MMP		TIMP-1		TIMP-2
	LEP	INV	LEP	INV	LEP	INV	LEP	INV	LEP	INV
Adenocarcinoma
1	−	−	2	3	1	1	1	3	2	3
2	+	−	1	2	0	0	0	1	0	1
3	+	−	1	2	0	1	0	2	1	2
4	+	−	1	2	1	1	2	3	1	2
5	−	−	2	2	1	2	0	0	0	0
6	+	−	1	1	1	2	0	1	1	1
7	+	−	1	1	0	0	1	3	1	2
8	−	−	2	3	1	3	0	2	1	1
9	−	−	2	3	1	2	0	2	0	3
10	+	−	1	3	2	2	0	0	0	1
11	+	−	2	3	1	1	1	1	0	0
12	−	−	2	3	1	2	1	2	0	2
13	+	−	1	3	2	2	1	2	1	3
14	−	−	2	2	1	3	1	3	0	2
15	+	+	0	1	2	2	2	3	2	3
16	−	−	2	3	2	2	3	3	2	3
17	+	+	1	3	1	2	3	3	0	2
18	−	−	3	3	2	3	1	3	1	3
19	+	−	1	2	3	3	1	3	1	2
20	+	−	1	2	2	2	0	1	0	1
21	−	−	2	3	2	1	3	3	2	3
22	+	+	1	3	1	3	2	3	1	3
23	−	−	2	2	2	2	1	2	1	3
24	+	−	1	3	1	3	1	3	1	2
25	+	−	2	3	3	3	1	3	2	3
26	−	−	2	2	1	1	1	1	1	1
27	+	−	1	3	0	1	1	3	3	3
Atypical adenomatous hyperplasia
1	+		2		0		1		1
2	+		0		0		1		0
3	+		2		0		1		0
4	+		1		0		1		0
5	+		0		0		1		1

Note: Staining was graded as 0, absent; 1, mild; 2, moderate; 3, strong: −, type IV collagen was destroyed; +, remained.

Abbreviations: LEP, lepidic area; INV, invasive area.