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. 2001 Dec;159(6):2355–2369. doi: 10.1016/S0002-9440(10)63085-4

Figure 4.

Figure 4.

Morphological features of renal involvement in TSLP transgenic mice. A: Wild-type male at the age of 199 days (silver stain; original magnification, ×1000). B: TSLP transgenic female at the age of 71 days. The glomerular tuft shows prominent increase of agyrophil mesangial matrix (arrow; silver stain; original magnification, ×1000). C and D: Transgenic male at the age of 140 days. Deposition of PAS-positive material in peripheral capillaries and the mesangium (PAS stain; original magnification, ×1000). D and E illustrate the severity of the glomerular lesion with massive deposition of PAS-positive material (D) that is not agyrophil in the silver stain (E, original magnification, ×400). Note the normal tubulointerstitium in contrast to the severe glomerular lesion. F: Thickened glomerular capillary loop with a double contour (arrow) in a 137-day-old TSLP transgenic male (silver stain; original magnification, ×1000).