Table 1.
Clinical Data of the Study Group
| Male wild type | Male TSLP transgenic | Female wild type | Female TSLP transgenic | |
|---|---|---|---|---|
| n | 38 | 37 | 24 | 24 |
| Body weight (range, g) | 10.6–32.0 | 6.0–31.0 | 11.0–25.0 | 6.2–22 |
| Ear involvement | 0 | 22% | 0 | 4% |
| Cryoglobulins | 0 | 81% | 0 | 90% |
| Blood urea nitrogen (mg/dl, n = 98) | 21.3(n = 31) | 25.7*(n = 29) | 23.0(n = 21) | 29.3*(n = 17) |
| μg Albumin/mg creatinine (±SEM; n = 46) | 64 (±11)(n = 16) | 150 (±23)*(n = 18) | 45 (±14)(n = 7) | 245 (±89)*(n = 5) |
| Heart weight (g, % body weight) | 0.13 (0.6%) | 0.14 (0.6%) | 0.1 (0.6%) | 0.11 (0.7%) |
| Kidney weight (g, % body weight) | 0.39 (1.7%) | 0.31 (1.4%) | 0.23 (1.4%) | 0.22 (1.4%) |
| Lung weight (g, % body weight) | 0.16 (0.7%) | 0.43‡ (1.9%†) | 0.16 (0.9%) | 0.37‡ (2.3%†) |
| Liver weight (g, % body weight) | 1.15 (4.9%) | 1.43* (6.3%†) | 0.8 (4.5%) | 1.04 (6.6%†) |
| Spleen weight (g, % body weight) | 0.08 (1.8%) | 0.39‡ (3.5%†) | 0.08 (2.6%) | 0.39‡ (4.7%†) |
*P < 0.05, †P < 0.01, ‡P < 0.001, versus wild type.