Figure 2.

Clustering of the 874 genes. Each line across all comparisons represents a single gene with up-regulation indicated in increasing red and down-regulation indicated in increasing green. Genes were clustered according to the nature and extent of their differential expression; the four comparisons of HCV cirrhosis, AIH cirrhosis, PBC cirrhosis, and PSC cirrhosis to nondiseased tissue (A) and HCV cirrhosis and AIH cirrhosis compared to each other as well as to nondiseased tissue (B). There was ∼50% similarity expression in the various forms of cirrhosis in (A) and >70% similarity in the patterns of expression in hepatitic HCV- and AIH-associated cirrhosis compared to nondiseased tissue (B, indicated in both instances by the dashed line with an asterisk). This graphical depiction of the data identifies groups of genes, such as those that appear uniquely expressed in HCV compared to other forms of cirrhosis with either increased (I) or decreased (II) expression compared to nondiseased tissue. Further, increased gene expression in hepatitic cirrhosis (B) showed genes with increased expression in HCV-associated cirrhosis compared to both nondiseased tissue and AIH-associated cirrhosis (III), both HCV- and AIH-associated cirrhosis compared to nondiseased liver tissue (IV and V), HCV-associated cirrhosis compared to AIH-associated cirrhosis in addition to both of these diseases compared to nondiseased liver tissue (V), and AIH- but not HCV-associated cirrhosis compared to nondiseased tissue (VI).