Table 2.
Patient and Polyp Characteristics in Relation to CIMP Status of Hyperplastic Polyps in Patients with Multiple/Large HPs or Hyperplastic Polyposis, Odds Ratio, and 95% Confidence Intervals (CI) from Generalized Estimating Equation Marginal Regression Models
| Factors | CIMP-negative, % (fraction) | CIMP-low, % (fraction) | CIMP-high, % (fraction) | Odds ratio (CI) | Chi-square | P value |
|---|---|---|---|---|---|---|
| Patient characteristics | ||||||
| With serrated adenoma | ||||||
| Predominance of HPs in right colon | 0 (0/23) | 13 (3/23) | 87 (20/23) | 27.55 (7.3, 103.6) | 16.52 | 0.009 |
| Predominance of HPs in left colorectum | 17 (2/12) | 8 (1/12) | 75 (9/12) | 9.55 (3.7, 24.5) | ||
| Without serrated adenoma | ||||||
| Predominance of HPs in right colon | 24 (5/21) | 14 (3/21) | 62 (13/21) | 4.60 (1.5, 13.7) | ||
| Predominance of HPs in left colorectum | 78 (36/46) | 17 (8/46) | 4 (2/46) | 1.00 | ||
| Age (continuous, years) | — | — | — | 1.02 (0.98, 1.8) | 1.52 | 0.22 |
| Hyperplastic polyp characteristics | ||||||
| Site | ||||||
| Left | 66 (38/58) | 16 (9/58) | 19 (11/58) | 0.39 (0.1, 1.1) | 2.63 | 0.10 |
| Right | 11 (5/44) | 14 (6/44) | 75 (33/44) | 1.00 | ||
| Size (continuous, mean± SD, mm) | 3.0± 1.5 | 3.1± 1.6 | 5.1± 4.3 | 1.04 (0.9, 1.2) | 0.70 | 0.40 |
| K-ras mutation | ||||||
| Absent | 40 (37/92) | 12 (11/92) | 48 (44/92) | 5.08 (1.5, 17.6) | 4.72 | 0.03 |
| Present | 70 (7/10) | 30 (3/10) | 0 | 1.00 | ||
| 1p loss | ||||||
| Absent | 41 (39/95) | 14 (13/95) | 45 (43/95) | 3.24 (0.7, 15.7) | 1.94 | 0.16 |
| Present | 71 (5/7) | 14 (1/7) | 14 (1/7) | 1.00 |