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The effects of inhibitors of integrin-mediated cell signaling. Increasing concentrations of the tyrosine kinase inhibitor genistein (A) or the phosphatidylinositol-3-kinase inhibitors LY294002 (B) and wortmannin (C) were added during the induction of macrophage fusion/FBGC formation (day 3 to day 7) as described in Materials and Methods. Results are expressed as the percent adhesion of untreated control cells, n = 3 monocyte donors.
