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. 2002 Jul;161(1):173–182. doi: 10.1016/S0002-9440(10)64169-7

Figure 6.

Figure 6.

Proliferative CE cell populations function independently of PNECs/NEBs in the terminal bronchiole. Adjacent serial section immunostaining for CCSP (A and C) and CGRP (B and D) was coupled with autoradiography (black grains) to determine whether terminal bronchiolar proliferation was preferentially associated with CGRP-immunopositive PNECs/NEBs. The majority (75%) of terminal bronchioles contain numerous mitotic CE cells adjacent to the BADJ (A) yet lack any CGRP-positive PNECs/NEBs in the adjacent serial section (B) 36 hours after 275 mg/kg of naphthalene. A minority of terminal bronchioles (25%) appear to contain both CCSP (C)- and CGRP (D)-positive mitotic cells by adjacent serial section analysis. Interestingly, the occurrence of NEBs (C and D, asterisks) appeared to relax the requirement for BADJ association among proliferating CE cells of the terminal bronchiole (black grains; A and B versus C and D).