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. 2002 Jul;161(1):183–193. doi: 10.1016/s0002-9440(10)64170-3

Figure 7.

Figure 7.

MMP-2 activates endogenous TGF-β1 and stimulates α3-integrin expression and migratory activity on HepG2-noninvading cells. The active TGF-β1 concentration is increased in the conditioned media of HepG2-noninvading cells cultured in the presence of MMP-2 (A). Each bar represents the mean of three different experiments. HepG2-α3-integrin expression is increased after incubation with TGF-β1 or with active MMP-2, as evaluated by FACS analysis (B). α3-integrin RNA is expressed in Sk-Hep1 invasive cells but not in HepG2-noninvading cells. After incubation with TGF-β1 or with active MMP-2 HepG2 cells express α3-integrin RNA (C). HepG2 migration on Ln-5 occurs only in MMP-2- and TGF-β1-cultured cells (D).