Figure 1.

Effect of peptides on gp120_JR-FL binding to CCR5. L1.2-CCR5⁺ cells were incubated with the biotinylated gp120_JR-FL/CD4-IgG₂ complex in the presence of different concentrations of peptides (a) S-3/10/14, S-10/14, S-10, S-14, or (b) P-3/10/14, P-10/14, SS-2/12, SS-10/14, TS-10/14. The extent of complex binding in the absence of peptide was defined as 100% (m.f.i. ≈40 ± 5). Binding in the presence of peptide is expressed as a percentage of control. When CCR5-negative cells were used, binding of the gp120_JR-FL/CD4-IgG2 complex was negligible (≈10%, m.f.i. ≈2 ± 1). The values shown are from a sample experiment.