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. 2002 Jul;161(1):163–171. doi: 10.1016/S0002-9440(10)64168-5

Figure 2.

Figure 2.

Relationship between p27Kip1 expression and B-cell differentiation stage as defined by MUM1, BCL-6, and syn-1 in AIDS-related IBL. The figure shows a p27Kip1-positive IBL case that is associated with the BCL-6−/MUM1+/syn-1+ phenotypic pattern reflecting post-GC B cells. LMP1 is expressed by a fraction of large tumor cells. The staining is cytoplasmic and intense. In the figure numerous immunoblastic-plasmacytoid tumor cells show nuclear immunoreactivity with the anti-Ki-67 (MIB1) mAb. Furthermore, neoplastic cells display strong nuclear immunoreactivity with the anti-cyclin D3 mAb. Paraffin-embedded tissue sections, immunoperoxidase method (p27Kip1, Ki-67, cyclin D3, BCL-6, MUM1), alkaline phosphatase anti-alkaline phosphatase method (syn-1, LMP1), hematoxylin counterstain. Original magnifications, ×250.