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. 2002 Jul;161(1):163–171. doi: 10.1016/S0002-9440(10)64168-5

Figure 3.

Figure 3.

Relationship between p27Kip1 expression and B-cell differentiation stage as defined by MUM1, BCL-6, and syn-1 in AIDS-related large noncleaved cell lymphoma (LNCCL). The figure shows a p27Kip1-negative LNCCL case that is associated with the BCL-6+/MUM1−/syn-1− phenotypic pattern reflecting GC B cells. LMP1 is not expressed by tumor cells. In the figure several large tumor cells show nuclear immunoreactivity with the anti-Ki-67 (MIB1) mAb. Only few neoplastic cells display weak nuclear immunoreactivity with the anti-cyclin D3 mAb. Paraffin-embedded tissue sections, immunoperoxidase method (p27Kip1, Ki-67, cyclin D3, BCL-6, MUM1), alkaline phosphatase anti-alkaline phosphatase method (syn-1, LMP1), hematoxylin counterstain. Original magnifications, ×250.