Table 4.
Relationship between p27Kip1 Expression and B-Cell Differentiation Stage as Defined by MUM1, BCL-6, and syn-1 in Acquired Immune Deficiency Syndrome-Related Non-Hodgkin’s Lymphomas (AIDS-NHL)
| Major phenotypic patterns | ||||||||
|---|---|---|---|---|---|---|---|---|
| BCL6+/MUM1−/syn-1− | BCL6+/MUM1+/syn-1− | BCL6−/MUM1+/syn-1− | BCL6−/MUM1+/syn-1+ | |||||
| p27+ | p27− | p27+ | p27− | p27+ | p27− | p27+ | p27− | |
| Systemic AIDS-NHL | ||||||||
| BL (n = 29) | 4 | 21 | 0 | 4 | 0 | 0 | 0 | 0 |
| LNCCL (n = 33) | 0 | 26 | 1 | 4 | 0 | 1 | 0 | 0 |
| IBL (n = 24) | 0 | 0 | 0 | 0 | 3 | 3 | 16 | 2 |
| AIDS-PCNSL | ||||||||
| LNCCL (n = 2) | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| LNCCL/IBL (n = 4) | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| IBL (n = 14) | 0 | 0 | 0 | 0 | 2 | 1 | 8 | 2 |
| EBV-positive (n = 58) | 1 | 17 | 3 | 3 | 4 | 4 | 18 | 4 |
| LMP1-positive (n = 28) | 0 | 0 | 1 | 0 | 2 | 3 | 14 | 4 |
Abbreviations: BL, Burkitt’s lymphoma; LNCCL, large noncleaved cell lymphoma; IBL, immunoblastic lymphoma; PCNSL, primary central nervous system lymphoma.
Minor phenotypic patterns included: BCL6−/MUM1−/syn1− in one systemic NHL (with LNCCL morphology) that scored negative for p27Kip1; BCL6−/MUM1−/syn1+ in one PCNSL (with IBL morphology) that scored negative for p27Kip1; BCL6+/MUM1+/syn1+ in two PCNSL (with LNCCL/IBL morphology) one of which scored positive for p27Kip1; and BCL6+/MUM1−/syn1+ in one PCNSL (with LNCCL/IBL morphology) that scored negative for p27Kip1.