Table 2.
Identified Known Genes Regulated by TGF-β1 in Normal Breast Fibroblasts
| Regulated genes | Status in TGF-β1-activated cells |
|---|---|
| Enzymes | |
| HPK/GCK-like kinase | ↑ |
| Human 68kD PIP5 KI α1 | ↑ |
| Human Krit 1 | ↑ |
| Lactate dehydrogenase | ↓ |
| NADH4 | ↑ |
| N-terminal acetyl transferase ard1 subunit | ↓ |
| PAPS synthetase 2 | ↑ |
| PI kinase | ↑ |
| Putative helicase | ↑ |
| SnoN2 | ↑ |
| SOD-1 | ↓ |
| Transcription factors | |
| Cyclin I | ↓ |
| EF-1α | ↑ |
| TIF-1 | ↓ |
| Transport proteins | |
| Metallothionein | ↑ |
| High-density lipoprotein-binding protein | ↑ |
| Putative Cl− channel | ↑ |
| ECM modulators | |
| Collagen X | ↑ |
| Fibronectin | ↑ |
| Lysyl oxidase | ↓ |
| TIMP3 | ↑ |
| Cytokines and receptors | |
| Eotaxin | ↓ |
| HGF-like activator | ↑ |
| KGF | ↓ |
| Lipocortin/annexin | ↑ |
| TGF-β3R | ↓ |
| Structure/motility proteins | |
| Ankyrin-like protein | ↓ |
| Cornichon-like mRNA | ↓ |
| Myosin I heavy chain | ↑ |
| Myosin class I myh-1c | ↓ |
| Others | |
| GW128 mRNA | ↑ |
| TGF-β1-induced mRNA | ↑ |
| KIAA0551 protein mRNA | ↑ |
| KIAA1334 protein mRNA | ↑ |
| WBSCR 9 mRNA | ↓ |