Figure 4.
Tissue β-galactosidase expression in adult pSG-MAR-12166 transgenic mice. Renin and LacZ expression were measured in various tissues of transgenic mice. β-Galactosidase activity was expressed as relative β-galactosidase activity/μg protein. Renin activity was measured by RIA. A shows that β-galactosidase is mainly expressed in kidney, and to a lesser extent in adrenal gland and brain. Other tissues express very low levels or no β-galactosidase. B shows a good correlation (r = 0.93, P < 10−3) between β-galactosidase activity and mouse renin activity in these tissues.