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. 2002 Aug;161(2):643–654. doi: 10.1016/S0002-9440(10)64220-4

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Copyright © 2002, American Society for Investigative Pathology

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Figure 1. — A: Flow cytometric analysis of TRAIL receptors in TRAIL-sensitive SW579 and TRAIL-resistant SW579-TR cells was performed to determine the cell surface expression of TRAIL receptors DR4, DR5, DcR1, and DcR2 (shaded peaks). Control antibody staining appears as unshaded peaks. B: Immunoblotting for caspase-10 in TRAIL-sensitive parental (SW579) and TRAIL-resistant (SW579-TR) thyroid carcinoma cells. Caspase-10 was cleaved on TRAIL treatment in parental SW579 cells, but not in TRAIL-resistant SW579-TR. C: Caspase-8 activity was determined by use of the ApoAlert caspase-8 activity colorimetric assay kit in TRAIL-sensitive parental (SW579) and TRAIL-resistant (SW579-TR) thyroid carcinoma cells treated with (black bars) or without (white bars) 100 ng/ml of TRAIL for 4 hours. TRAIL induced caspase-8 activation in parental, but not in resistant cells.