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. 2002 Aug;161(2):643–654. doi: 10.1016/S0002-9440(10)64220-4

Figure 11.

Figure 11.

A and B: Flow cytometric analysis of TRAIL receptors DR4 (A) and DR5 (B) after a 48-hour treatment with or without IFN-γ (500 IU/ml) or TNF-α (50 ng/ml) in SW579 cells. Control antibody staining is also shown. C: Evaluation of the protein levels of caspase-8, caspase-10, caspase-3, FLIP, and TRAIL in SW579 cells after a 48-hour treatment with or without IFN-γ (500 IU/ml) or TNF-α (50 ng/ml). IFN-γ (500 IU/ml) up-regulated caspase-8 and TNF-α (50 ng/ml) and up-regulated caspases-10 and -3. Additionally, TNF-α induced the expression of TRAIL itself.