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. 2002 Aug;161(2):643–654. doi: 10.1016/S0002-9440(10)64220-4

Figure 9.

Figure 9.

Impact of geldanamycin (GA) (1 μmol/L) on TRAIL-induced apoptosis in thyroid carcinoma cells. A: SW579 cells were pretreated with IGF-1 (100 ng/ml) for 6 hours, in the presence or absence of geldanamycin, and then incubated with LZ-TRAIL (50 ng/ml) for an additional 18 hours. Geldanamycin overcame the protective effect of IGF-1 against TRAIL-induced apoptosis. Moreover, geldanamycin alone had a sensitizing effect on TRAIL-induced apoptosis. B: Geldanamycin also sensitized SW579 cells to the Apo2L form of the ligand (50 ng/ml).