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LTC4/LTD4 conversion activity in different fractions of spleen from WT (□), GGT−/− (▪), and GGL−/− (▨) mice. The cleavage of LTC4 was analyzed by HPLC as described in Materials and Methods. The specific activity is expressed as nmol/mg protein/hour (n = 3). Values are mean ± SEM. *, Significant difference from the other two groups (P < 0.01) by Student’s t-test.
