Figure 4.

Analysis of plasma leukotrienes after exogenous administration of LTC₄. HPLC was applied as described in Materials and Methods. A, WT; B, GGT-deficient; C, GGL-deficient; D, GGT/GGL-deficient; E, WT pretreated with d-penicillamine; F, GGT-deficient pretreated with d-penicillamine. LTC₄, LTD₄, and LTE₄ peaks were authenticated by comparing them with retention times of external standards. 12,13 Peak UI is an unidentified peak that is also observed in the control plasmas (no exogenous LTC₄ administration) (data not shown). Three mice were used for each group, and all mice in the same group showed similar results.