Figure 5.

Analysis on BALF Cyst LTs levels in mice with experimental asthma. A: LTC₄ levels in BALF. B: LTE₄ levels in BALF. C: AHR after acetylcholine challenge. AHR was measured as the amount of acetylcholine that induced a 200% rise in pulmonary resistance from the baseline during challenge (PC₂₀₀). WT, GGL^−/−, GGT^−/−, and GGL^−/−/GGT^−/− mice were treated with PBS (□) or CF (▪). Data are representative of two separate experiments with seven to eight mice per group and are plotted as means ± SEM *, Significant differences (P < 0.01) between PBS treatment and CF treatment; #, significant differences (P < 0.01) from the WT group, by Student’s t-test.