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. 2002 Aug;161(2):565–574. doi: 10.1016/S0002-9440(10)64212-5

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Copyright © 2002, American Society for Investigative Pathology

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Figure 2. — Examples of liver repopulation after bone marrow transplantation. a and b: β-galactosidase whole mount staining of liver. c and d: FAH immunohistochemistry. a: Effect of NTBC withdrawal. Top: Liver samples from animals kept on NTBC for 28 weeks after BMT. Bottom: Samples from mice that were off for 22 to 28 weeks. Significant repopulation (blue clusters) was present only in animals off NTBC. b: Effects of total body irradiation. The upper liver sample was from an irradiated recipient and the lower from a control animal transplanted with the same bone marrow cells, but without total body irradiation. c: Single FAH-positive hepatocyte (arrow) found 7 weeks after BMT (original magnification, ×200). d: FAH-positive cluster 11 weeks after BMT (original magnification, ×400).