Figure 3.

Survival outcomes based on 3q status. Curves were generated by the Kaplan-Meier method and compared using the log rank test. All P values are two-sided and considered statistically significant if less than or equal to 0.05. A: Probability of disease-free survival was significantly poorer in patients with 3q26.3 amplification identified by FISH than in those with normal copy number (P = 0.001). Multivariate analysis, including 3q copy number status, TNM stage, and treatment type, revealed that only high-level amplification (>4 X copy number) remained an independent predictor of disease-free survival with a relative risk of 5.1 (95% confidence interval, 1.9 to 13.9). B: Probability of cause-specific survival was significantly poorer for patients with 3q amplification (P = 0.006). Multivariate analysis, including 3q copy number status, TNM stage, and treatment type, revealed that only high-level amplification (>4 X copy number) remained an independent predictor of disease-free survival with a relative risk of 7.6 (95% confidence interval, 1.9 to 24.6).