Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Proposed model of E-cadherin dependent carcinogenesis pathways of diffuse type (a) and intestinal type gastric cancer (b). Based on our findings, we propose a key role for the E- to N-cadherin switch, beside loss of E-cadherin function through gene mutations, in diffuse type gastric carcinoma. In intestinal type gastric carcinoma, enhanced SIP1 expression may be involved in tumor progression due to E-cadherin repression.
