Figure 1.

Topography of DCs in normal and inflamed arteries. Paraffin-embedded temporal arteries that were either normal or affected by GCA were stained with anti-S-100 Ab and developed with ABC-IP and AEC (Vector Laboratories). In arteries with GCA, S-100⁺ DCs were found in the media and the adventitia (black arrow, media-adventitia border), often tracking with the mononuclear infiltrates (A and B). Selected multinucleated giant cells (GCs) were positive for the S-100 marker (C). Normal arteries contained a distinct population of S-100⁺ DCs arranged in the proximal adventitia along the lamina elastica externa (yellow arrows, D). Original magnifications: ×100 (A); ×400 (B–D).