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. 2002 Jun;160(6):2207–2217. doi: 10.1016/S0002-9440(10)61168-6

Figure 1.

Figure 1.

Caveolin-1/3 dKO mice are deficient in the expression of all three members of the caveolin gene family (Cav-1, -2, and -3). Protein expression of caveolin family members was examined in wild-type and Cav-1/3 dKO mice. Note that in wild-type mice, fat and lung tissues abundantly express Cav-1 and Cav-2 proteins, while Cav-3 is abundantly expressed in striated muscle tissues, and all three caveolin family members are expressed in the vasculature (as in the aorta). Immunoblot analysis using isoform-specific caveolin mAb probes demonstrates a loss of Cav-1 and Cav-3 protein expression in all of the Cav-1/3 dKO tissues examined. Note that as Cav-2 requires Cav-1 for stabilization, oligomerization, and plasma membrane localization, Cav-2 protein expression is also dramatically down-regulated (by ∼95%) in Cav-1/3 dKO mice.