Table 3.
Heart Rate and Echocardiographic Data from WT and Cav-1/3 dKO Mice at 2 and 4 Months
| Group | Heart rate (bpm) | End diastolic diameter (mm) | End systolic diameter (mm) | Intraventricular septal thickness (mm) | Posterior wall thickness (mm) | Wall thickness diastole (mm) | Relative wall thickness (ratio) | Fractional shortening (%) |
|---|---|---|---|---|---|---|---|---|
| 2 months of age | ||||||||
| WT | 652 ± 69 | 2.71 ± 0.16 | 1.12 ± 0.13 | 0.74 ± 0.03 | 0.76 ± 0.04 | 0.75 ± 0.03 | 0.55 ± 0.03 | 58.65 ± 5.48 |
| dKO | 631 ± 61 | 3.27 ± 0.16† | 2.02 ± 0.07* | 0.99 ± 0.08* | 0.99 ± 0.06* | 0.99 ± 0.06* | 0.60 ± 0.04 | 38.33 ± 2.57† |
| 4 months of age | ||||||||
| WT | 612 ± 111 | 2.81 ± 0.11 | 1.28 ± 0.25 | 0.74 ± 0.07 | 0.75 ± 0.07 | 0.74 ± 0.07 | 0.53 ± 0.04 | 54.47 ± 7.68 |
| dKO | 674 ± 74 | 3.24 ± 0.13* | 1.92 ± 0.18† | 0.98 ± 0.07* | 0.97 ± 0.06* | 0.98 ± 0.06* | 0.60 ± 0.04‡ | 40.87 ± 4.50‡ |
n ≥ 4 for each experimental group.
P < 0.0007;
†P < 0.003;
‡P < 0.02.