Table 3A.
Early Genes Up-Regulated by SP, LPS, and Antigen-Induced Bladder Inflammation
| Group | Abbreviation | Gene | GenBank | Antigen | Substance P | LPS | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 4 | 24 | 1 | 4 | 24 | 1 | 4 | 24 | ||||
| Adhesion | semaphorin IIIB | Semaphorin IIIB | X85990 | 3.0 | 1.0 | 1.0 | 3.0 | 1.0 | 1.0 | 3.0 | 1.5 | 1.3 |
| Basic Transcription Factors | CUTL2 | Cut-related homeobox-2 | U45665 | 5.5 | 2.2 | 2.7 | 4.0 | 0.5 | 1.1 | 3.4 | 0.8 | 1.0 |
| Basic Transcription Factors | SOX13 | HMG-box transcription factor | AJ000740 | 3.0 | 1.0 | 0.3 | 3.0 | 0.8 | 1.0 | 3.0 | 1.0 | 1.0 |
| Cytoskeleton & Motility Proteins | vitronectin | Vitronectin precursor | X72091 | 3.8 | 1.0 | 1.0 | 3.8 | 1.0 | 1.0 | 3.8 | 1.2 | 1.0 |
| Growth Factors and Cytokines | FGF 9 | Fibroblast growth factor 9 | D38258 | 3.6 | 1.6 | 0.5 | 3.6 | 1.6 | 1.0 | 3.6 | 1.6 | 1.0 |
| Growth Factors and Cytokines | MIP2-alpha | Macrophage inflamatory protein 2 alpha | X53798 | 3.7 | 1.0 | 1.0 | 3.7 | 1.0 | 1.0 | 3.7 | 1.0 | 1.0 |
| Growth Factors and Cytokines | VEGF | Vascular endothelial growth factor | M95200 | 3.7 | 1.0 | 0.4 | 3.7 | 1.0 | 1.0 | 8.6 | 1.7 | 1.0 |
| Growth Factors and Cytokines | WNT5B | Wingless-related MMTV integration | M89799 | 3.7 | 1.0 | 1.2 | 3.7 | 1.0 | 1.0 | 3.7 | 0.9 | 1.0 |
| Hormone Receptors | CRF R | Corticotropin releasing factor receptor | X72305 | 3.8 | 1.0 | 1.0 | 3.8 | 1.0 | 1.0 | 3.8 | 1.0 | 1.0 |
| Hormone Receptors | estrogen R | Estrogen receptor | M38651 | 3.1 | 1.0 | 1.0 | 3.1 | 1.0 | 1.0 | 3.1 | 0.4 | 1.0 |
| Hormone Receptors | galanin R 1 | Galanin receptor 1 | U90657 | 3.1 | 1.0 | 1.0 | 3.1 | 1.0 | 0.3 | 3.1 | 1.9 | 1.0 |
| Hormone Receptors | melanocortin 5 R | Melanocortin 5 receptor | X76295 | 3.4 | 1.0 | 1.0 | 3.4 | 1.0 | 1.0 | 3.4 | 0.5 | 1.0 |
| Intracellular Transducers | TAK1 | TGF-beta-activated kinase 1 | D76446 | 3.1 | 1.0 | 0.3 | 3.1 | 1.0 | 1.0 | 3.1 | 1.0 | 1.0 |
| Neuropeptides | proenkephalin B | Proenkephalin B precursor | AF026537 | 3.1 | 0.5 | 3.6 | 4.1 | 1.1 | 1.8 | 3.1 | 0.9 | 1.7 |
| Neurotransmitter Receptors | ACH R | Acetylcholine receptor alpha | M17640 | 3.1 | 1.0 | 1.0 | 3.1 | 1.0 | 1.0 | 3.1 | 1.0 | 1.0 |
| Neurotransmitter Receptors | GABRA1 | Gamma-aminobutyric-acid R alpha-1 | M86566 | 4.6 | 1.0 | 0.6 | 3.0 | 1.0 | 1.0 | 3.0 | 1.0 | 1.0 |
| Neurotrophins | beta-NGF | Nerve growth factor beta precursor | K01759 | 3.6 | 1.0 | 1.0 | 3.6 | 1.0 | 1.0 | 3.6 | 0.5 | 1.0 |
| Oncogenes | c-fos | c-fos | V00727 | 3.0 | 0.4 | 0.3 | 3.9 | 0.4 | 1.4 | 5.7 | 2.3 | 2.7 |
| Oncogenes | fos-B | Fos-B | X14897 | 0.9 | 0.9 | 4.4 | 3.0 | 1.0 | 1.0 | 3.0 | 0.8 | 1.0 |
| Phospholipases & Phosphoinositol | PLC gamma | Phospholipase C gamma | X95346 | 1.1 | 0.3 | 3.0 | 5.5 | 1.0 | 1.3 | 17.0 | 3.6 | 2.6 |
Ratio of Gene Expression (Treatment/Saline) was calculated from individual expressions as % of beta-actin.
Numbers in bold indicate peak of gene expression.