Table 3B.
Intermediate Genes Up-Regulated by SP, LPS, and Antigen-Induced Bladder Inflammation
| Group | Abbreviation | Gene | GenBank | Antigen | Substance P | LPS | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 4 | 24 | 1 | 4 | 24 | 1 | 4 | 24 | ||||
| Adenylate/Guanylate Cyclases | PDE 1C | Phosphodiesterase 1C | L76946 | 1.5 | 3.9 | 3.9 | 1.5 | 3.9 | 3.9 | 0.6 | 3.1 | 1.0 |
| Apoptosis | INOS | Inducible nitric oxide synthase | M87039 | 1.2 | 3.0 | 1.1 | 1.2 | 3.0 | 1.0 | 1.2 | 3.0 | 1.0 |
| Basic Transcription Factors | FOG | Friend of GATA 1 | AF006492 | 1.0 | 3.8 | 0.3 | 1.0 | 3.8 | 1.0 | 1.0 | 3.8 | 1.0 |
| Basic Transcription Factors | FREAC7 | Forkhead-related TF7 | X92498 | 1.7 | 3.4 | 0.5 | 0.5 | 3.4 | 0.4 | 1.7 | 3.4 | 1.0 |
| Basic Transcription Factors | GTX | Homeobox protein GTX | L08074 | 1.0 | 3.5 | 0.3 | 1.0 | 3.5 | 1.0 | 1.0 | 3.5 | 1.0 |
| Basic Transcription Factors | maf1 | Transcription factor | L36435 | 1.0 | 3.0 | 0.7 | 1.0 | 3.0 | 0.3 | 1.0 | 3.5 | 1.0 |
| Basic Transcription Factors | NKX-3.2 | Drosophila NK3 TF | U87957 | 0.4 | 3.4 | 2.4 | 0.5 | 3.4 | 0.5 | 1.5 | 3.4 | 1.0 |
| CDK Inhibitors | p57kip2 | Cdk-inhibitor kip2 | U20553 | 1.0 | 3.9 | 1.0 | 1.0 | 3.9 | 1.0 | 1.0 | 4.7 | 1.5 |
| Cell Cycle-Related Proteins | PK cAMP | Protein kinase, cAMP dependent | X61434 | 4.8 | 2.1 | 4.1 | 1.3 | 0.9 | 3.9 | 3.6 | 1.1 | 1.0 |
| Cytoskeleton & Motility Proteins | NEFM | Neurofilament triplet M protein | X05640 | 1.2 | 3.1 | 1.0 | 1.2 | 3.1 | 0.3 | 1.2 | 4.1 | 1.0 |
| Intracellular Kinase Network Members | WBP6 | WW domain binding protein 6 serine K | U92456 | 1.0 | 3.2 | 1.0 | 1.0 | 3.2 | 1.0 | 1.0 | 3.2 | 1.0 |
| Intracellular Transducers | DIDFF | DNase inhibited by DNA fragmentation | AB009377 | 1.0 | 3.9 | 1.0 | 1.0 | 3.9 | 1.0 | 1.0 | 3.4 | 1.0 |
| Intracellular Transducers | PAR4 | Protease-activated receptor 4 | AF080215 | 1.0 | 3.9 | 1.0 | 1.0 | 3.9 | 1.0 | 1.0 | 3.7 | 1.0 |
| Neuropeptides | orphanin | Nociceptin precursor FQ | D82866 | 0.6 | 3.4 | 2.3 | 0.6 | 3.4 | 0.9 | 0.6 | 2.6 | 3.0 |
| Oncogenes & Tumor Suppressors | mybL2 | Myb-related protein B | X70472 | 1.0 | 3.8 | 1.4 | 1.0 | 3.8 | 0.3 | 1.0 | 4.1 | 1.0 |
| Transcription Activators & Repressors | EKLF | Erythroid Kruppel-like | M97200 | 1.0 | 3.0 | 1.0 | 0.4 | 3.0 | 1.0 | 1.0 | 4.2 | 3.9 |
| Transcription Activators & Repressors | IRF1 | Interferon regulatory factor 1 | M21065 | 2.9 | 4.4 | 2.7 | 0.8 | 3.1 | 1.5 | 10.1 | 10.8 | 1.0 |
| Transcription Activators & Repressors | NF-kB p105 | Nuclear factor kappaB p105 | M57999 | 1.0 | 3.8 | 0.7 | 1.0 | 3.8 | 1.0 | 1.0 | 26.7 | 2.4 |
| Transcription Activators & Repressors | PGDH | D-3-phosphoglycerate dehydrogenase | L21027 | 0.7 | 3.2 | 0.7 | 1.4 | 3.2 | 0.3 | 1.4 | 4.2 | 1.0 |
Ratio of Gene Expression (Treatment/Saline) was calculated from individual expressions as % of beta-actin.
Numbers in bold indicate peak of gene expression.