Table 3C.
Late Genes Up-Regulated by SP, LPS, and Antigen-Induced Bladder Inflammation
| Group | Abbreviation | Gene | GenBank | Antigen | Substance P | LPS | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 4 | 24 | 1 | 4 | 24 | 1 | 4 | 24 | ||||
| Adhesion | occludin | Occludin | U49185 | 3.3 | 1.7 | 4.1 | 0.5 | 3.0 | 3.1 | 1.8 | 2.2 | 3.8 |
| Basic Transcription Factors | CLIM1B | Lim homeobox | U89487 | 1.0 | 1.0 | 3.4 | 1.0 | 1.0 | 3.6 | 1.0 | 1.0 | 3.3 |
| Basic Transcription Factors | PTC1 | Patched homolog 1 | U46155 | 0.3 | 1.0 | 3.4 | 1.0 | 1.0 | 3.4 | 1.0 | 1.0 | 3.8 |
| Death Receptors | CD 30L | CD 30L receptor | U25416 | 0.1 | 0.5 | 6.1 | 0.4 | 0.9 | 3.6 | 1.0 | 1.0 | 3.6 |
| Growth Factor & Chemokine Receptors | CD 40L R | CD 40L receptor | M83312 | 0.4 | 1.0 | 3.0 | 1.0 | 1.0 | 3.9 | 1.0 | 1.2 | 3.4 |
| Growth Factors and Cytokines | Lymphotoxin | Tumor necrosis factor beta | M16819 | 1.0 | 1.0 | 3.8 | 0.3 | 1.0 | 3.8 | 1.0 | 1.2 | 3.8 |
| Growth Factors and Cytokines | prepro-ET-3 | Prepro-endothelin-3 | U32330 | 2.5 | 1.4 | 3.9 | 2.5 | 1.4 | 3.9 | 2.5 | 0.7 | 3.3 |
| Growth Factors and Cytokines | THPO | Thrombopoietin precursor | L34169 | 1.0 | 1.0 | 3.8 | 1.0 | 1.0 | 3.8 | 1.0 | 0.5 | 3.7 |
| Intracellular Transducers | FZD9 | Frizzled homolog 9 | AF033585 | 1.0 | 1.0 | 4.0 | 1.0 | 1.0 | 4.0 | 1.0 | 1.0 | 3.5 |
| Intracellular Transducers | IFNgR2 | Interferon-gamma receptor | S69336 | 1.0 | 1.2 | 3.5 | 1.0 | 3.3 | 1.5 | 1.0 | 3.3 | 3.9 |
| Oncogenes & Tumor Suppressors | TSG101 | Tumor susceptibility protein 101 | U52945 | 2.5 | 1.3 | 7.9 | 0.7 | 0.8 | 3.0 | 1.7 | 2.1 | 4.0 |
| Protease Inhibitors | PAI2 | plasminogen activator inhibitor 2 | X16490 | 0.8 | 1.2 | 3.8 | 0.8 | 0.9 | 3.8 | 0.8 | 1.3 | 4.0 |
| Protease Inhibitors | PI 17 | Protease inhibitor 17 | AJ001700 | 1.7 | 0.4 | 3.8 | 1.7 | 1.0 | 3.8 | 1.7 | 1.0 | 2.7 |
| Proteases | Kininogen | Plasma kallikrein | M58588 | 1.0 | 1.0 | 4.0 | 1.0 | 0.6 | 4.0 | 1.0 | 0.7 | 3.9 |
| Recombination Proteins | DMC1 | Meiotic recombination protein | D64107 | 2.4 | 0.4 | 3.7 | 2.4 | 1.0 | 3.7 | 6.5 | 0.5 | 3.6 |
| Unclassified Proteins | formin 4 | Formin 4 | X62379 | 0.8 | 1.3 | 3.1 | 0.8 | 2.2 | 3.1 | 2.6 | 4.0 | 3.6 |
| Unclassified Proteins | huntingtin-AP | Huntingtin-associated | AJ000262 | 1.1 | 0.8 | 3.5 | 1.4 | 2.2 | 3.5 | 7.4 | 5.1 | 3.1 |
| Unclassified Proteins | PRESENILIN-1 | Presenilin-1 | AF007560 | 1.1 | 0.5 | 3.6 | 1.1 | 1.6 | 3.6 | 6.5 | 1.9 | 3.8 |
Ratio of Gene Expression (Treatment/Saline) was calculated from individual expressions as % of beta-actin.
Numbers in bold indicate peak of gene expression.