Table 5.
Supplemental Table 1 ▶ .
Genes Down-Regulated by SP, LPS, and Antigen-Induced Bladder Inflammation
| Group | Abbreviation | Gene | GenBank | Antigen | Substance P | LPS | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 4 | 24 | 1 | 4 | 24 | 1 | 4 | 24 | ||||
| Adhesion | DSG3 | Desmoglein 3 | U86016 | 1.0 | 3.0 | 0.3 | 2.2 | 3.2 | 0.9 | 1.0 | 3.2 | 0.3 |
| Apoptosis | presenilin 2 | Presenilin 2 | U57324 | 3.4 | 1.5 | 0.4 | 7.2 | 1.5 | 1.1 | 5.7 | 2.8 | 5.5 |
| ATPase Transporters | PMCA | Calcium-transporting ATPase | AF053471 | 3.1 | 0.5 | 2.1 | 1.9 | 0.3 | 3.3 | 4.3 | 0.1 | 1.0 |
| Basic Transcription Factors | EBF2 | Early B-cell factor 2 | U71189 | 3.5 | 1.0 | 0.5 | 3.2 | 1.0 | 0.3 | 3.2 | 1.8 | 0.3 |
| Basic Transcription Factors | PITX3 | Pituitary homeobox 3 protein | AF005772 | 4.3 | 7.8 | 1.6 | 4.6 | 1.9 | 0.5 | 3.1 | 2.9 | 0.4 |
| Caspases | ICE | Interleukin-converting enzyme | L28095 | 3.3 | 1.0 | 0.9 | 3.3 | 1.3 | 0.7 | 10.3 | 2.9 | 0.5 |
| Cell Cycle-Regulating Kinases | CKS-2 | Cyclin-dependent K regulatory subunit 2 | AA289122 | 0.9 | 3.6 | 0.7 | 0.9 | 3.6 | 0.7 | 0.8 | 4.7 | 0.7 |
| Cyclins | CCNA1 | G2/mitotic-specific cyclin A1 | X84311 | 8.2 | 29.9 | 3.0 | 1.7 | 5.5 | 0.5 | 1.9 | 2.0 | 4.1 |
| Cytoskeleton & Motility Proteins | COL6A1 | Collagen 6 alpha 1 subunit | X66405 | 8.3 | 7.2 | 1.5 | 3.1 | 2.0 | 1.0 | 1.5 | 3.4 | 3.6 |
| Cytoskeleton & Motility Proteins | CFL1 | Non-muscle cofilin 1 | D00472 | 2.9 | 12.5 | 1.8 | 2.1 | 3.2 | 1.2 | 1.6 | 3.4 | 6.2 |
| DNA Damage/Repair | UBE2B | Ubiquitin-conjugating enzyme E2 17-kDa | X96859 | 4.3 | 5.0 | 1.4 | 1.9 | 3.7 | 0.8 | 0.8 | 3.4 | 1.4 |
| DNA Damage/Repair | RAD23 | Excision repair protein homolog A | X92410 | 3.8 | 1.9 | 2.4 | 3.3 | 2.3 | 1.3 | 1.9 | 0.8 | 3.2 |
| Extracellular Transporters | LCAT | Lecithin-cholesterol acyltransferase | J05154 | 2.3 | 3.0 | 0.3 | 3.4 | 2.5 | 0.7 | 1.0 | 0.9 | 8.0 |
| Growth Factors and Cytokines | FGF-7 | Keratinocyte growth factor | Z22703 | 3.8 | 2.7 | 0.6 | 4.4 | 2.6 | 0.4 | 3.8 | 1.1 | 0.6 |
| Growth Factors and Cytokines | IGF-II | Insulin-like growth factor II precursor | M14951 | 3.8 | 4.4 | 2.6 | 1.9 | 3.5 | 0.5 | 2.7 | 3.5 | 1.0 |
| Intracellular Kinase | LIM | Domain kinase 1 | U15159 | 0.4 | 4.1 | 0.4 | 0.7 | 4.5 | 0.7 | 0.4 | 5.0 | 0.4 |
| Ion Channels (Membrane) | K 2 | Potassium channel, subfamily K | U73488 | 11.4 | 1.1 | 1.0 | 3.1 | 0.9 | 1.0 | 3.1 | 0.2 | 1.0 |
| Metalloproteinases | MMP14 | Matrix metalloproteinase 14 | X83536 | 3.9 | 2.6 | 0.8 | 4.2 | 2.2 | 0.8 | 2.5 | 3.7 | 0.8 |
| Metalloproteinases | MMP2 | Matrix metalloproteinase 2 | M84324 | 4.2 | 1.9 | 1.4 | 7.7 | 2.3 | 0.6 | 3.1 | 1.2 | 3.8 |
| Nucleotide Metabolism | PNMTase | Phenylethanolamine N-methyltransferase | L12687 | 3.2 | 0.7 | 0.6 | 2.6 | 0.4 | 3.4 | 4.2 | 0.3 | 1.0 |
| Symporters & Antiporters | VAT-1 | Synaptic vesicle membrane | X95562 | 4.5 | 1.4 | 1.4 | 6.3 | 3.8 | 2.4 | 10.0 | 0.7 | 0.7 |
| Transcription Activators & Repressors | HSF 2 | Heat shock transcription factor 2 | X61754 | 0.5 | 3.4 | 3.0 | 0.9 | 12.4 | 3.1 | 0.6 | 5.5 | 1.0 |
| Transcription Activators & Repressors | NF-kB p65 | NF-kappa-B transcription factor p65 | M61909 | 2.4 | 8.6 | 1.3 | 1.0 | 3.0 | 0.7 | 2.4 | 1.8 | 3.0 |
Ratio of Gene Expression (Treatment/Saline) was calculated from individual expressions as % of beta-actin.
Numbers in bold indicate peak of gene expression.