Table 6B.
Supplemental Table 2B ▶ .
Genes Down-Regulated by Substance P-Induced Bladder Inflammation
| Group | Abbreviation | Gene | GenBank | AG | SP | LPS | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 4 | 24 | 1 | 4 | 24 | 1 | 4 | 24 | ||||
| Adhesion | semaphorin N | semaphorin N | AF036585 | 0 | 1 | 0 | 3 | 2 | 0 | 2 | 2 | 1 |
| Apoptosis | mPIN | protein inhibitor of neuronal nitric oxide synthase | AF020185 | 1 | 1 | 0 | 5 | 4 | 1 | 1 | 1 | 2 |
| Apoptosis | DAD1 | defender against cell death 1 | U83628 | 2 | 1 | 0 | 5 | 2 | 1 | 1 | 0 | 1 |
| Aspartic Proteases | cathepsin D | cathepsin D | X53337 | 1 | 1 | 1 | 4 | 2 | 0 | 2 | 2 | 1 |
| Bcl Family | BAD | BCL2 binding component 6 | L37296 | 1 | 1 | 1 | 4 | 2 | 1 | 2 | 1 | 3 |
| Bcl Family | Mcl-1 | induced myeloid leukemia cell differentiation | U35623 | 1 | 0 | 0 | 3 | 1 | 1 | 1 | 1 | 1 |
| Bcl Family | BCLW | B-cell lymphoma protein W | U59746 | 1 | 1 | 0 | 4 | 2 | 1 | 2 | 1 | 1 |
| Bcl Family | BID | BH3 interacting domain death agonist | U75506 | 1 | 0 | 0 | 3 | 1 | 1 | 1 | 0 | 1 |
| Cell Cycle-Regulating Kinases | BUB1B | mitotic checkpoint protein kinase | AF107296 | 1 | 3 | 1 | 1 | 4 | 1 | 2 | 1 | 1 |
| Cell Signaling & Extracellular Communication | AMPA 1 | glutamate receptor; ionotropic | X57497 | 1 | 1 | 0 | 3 | 1 | 1 | 2 | 1 | 1 |
| Cytoskeleton & Motility | THB53 | thrombospondin 3 precursor | L04302 | 1 | 1 | 0 | 3 | 2 | 1 | 2 | 2 | 2 |
| Cytoskeleton & Motility | CK13 | type I cytoskeletal keratin 13 | U13921 | 0 | 0 | 0 | 3 | 1 | 1 | 2 | 0 | 1 |
| Cytoskeleton & Motility | LAMB3 | laminin beta 3 subunit precursor | U43298 | 1 | 1 | 1 | 3 | 2 | 1 | 2 | 1 | 0 |
| Death Receptor Ligands | TRAIL | TNF-related apoptosis inducing ligand | U37522 | 1 | 0 | 0 | 3 | 1 | 1 | 1 | 1 | 2 |
| Death Receptors | adenosine A1M | adenosine A1M receptor | U05671 | 1 | 1 | 0 | 3 | 2 | 1 | 2 | 1 | 1 |
| Death Receptors | RXR-beta | RXR-beta cis-11-retinoic acid receptor | X66224 | 2 | 2 | 1 | 4 | 1 | 1 | 1 | 1 | 1 |
| DNA Damage/Repair | MSH2 | DNA mismatch repair protein | U21011 | 1 | 1 | 1 | 4 | 3 | 1 | 2 | 1 | 2 |
| DNA Damage/Repair | Atm | ataxia telongiectasia murine homolog | U43678 | 1 | 0 | 0 | 3 | 1 | 1 | 2 | 1 | 1 |
| DNA Synthesis, Recombination & Repair Protein | MECP2 | methyl-CpG-binding protein 2 | AF072251 | 1 | 2 | 1 | 3 | 2 | 1 | 2 | 2 | 1 |
| G Protein-Coupled Receptors | adenosine A2b R | adenosine A2b receptor | U05673 | 1 | 2 | 1 | 3 | 1 | 1 | 1 | 2 | 2 |
| Growth Factor & Chemokine Receptors | CD28 precursor | T-cell-specific surface glycoprotein | M34563 | 2 | 1 | 0 | 4 | 2 | 1 | 1 | 1 | 2 |
| Growth Factor & Chemokine Receptors | GCSF | granulocyte colony—stimulating factor receptor | M58288 | 2 | 2 | 1 | 6 | 4 | 1 | 1 | 0 | 1 |
| Growth Factor & Chemokine Receptors | IGFR II | insulin-like growth factor receptor II | U04710 | 2 | 1 | 0 | 4 | 2 | 1 | 2 | 1 | 1 |
| Growth Factor & Chemokine Receptors | activin type I R | activin type I receptor | Z31663 | 2 | 2 | 0 | 5 | 3 | 1 | 1 | 1 | 1 |
| Growth Factors and Cytokines | FGF15 | fibroblast growth factor 15 | AF007268 | 1 | 0 | 0 | 4 | 1 | 1 | 2 | 1 | 3 |
| Growth Factors and Cytokines | WNT7A | wingless-related MMTV integration site 7A | M89801 | 2 | 1 | 2 | 3 | 1 | 1 | 2 | 1 | 1 |
| Growth Factors and Cytokines | WNT10A | wingless-related MMTV integration site 10A | U61969 | 1 | 0 | 1 | 4 | 1 | 1 | 2 | 1 | 3 |
| Growth Factors and Cytokines | FGF-7 | keratinocyte growth factor | Z22703 | 2 | 1 | 0 | 4 | 1 | 1 | 2 | 1 | 1 |
| Prostaglandin Receptors | prostaglandin F R | prostaglandin F receptor | D17433 | 2 | 1 | 1 | 3 | 1 | 1 | 2 | 1 | 1 |
| Hormone Receptors | insulin R | insulin receptor | J05149 | 2 | 2 | 2 | 3 | 3 | 1 | 2 | 3 | 1 |
| Hormone Receptors | PRLR2 | prolactin receptor | M22959 | 1 | 1 | 0 | 3 | 1 | 1 | 2 | 1 | 1 |
| Interleukin & Interferon Receptors | interleukin-8 R | interleukin-8 receptor | D17630 | 2 | 2 | 0 | 4 | 3 | 1 | 3 | 2 | 1 |
| Interleukin & Interferon Receptors | IL-5R alpha | interleukin-5 receptor alpha subunit | D90205 | 3 | 1 | 1 | 4 | 1 | 2 | 3 | 1 | 1 |
| Interleukins & Interferons | IL-10 | interleukin 10 | M37897 | 1 | 0 | 0 | 5 | 1 | 0 | 2 | 1 | 2 |
| Intracellular Transducers | RHOD | aplysia ras-related homolog D | D89821 | 0 | 0 | 0 | 4 | 2 | 1 | 1 | 1 | 1 |
| Ion Channels (Ligand-Gated) | nicotinic R | nicotinic acetylcholine receptor | M14537 | 1 | 2 | 1 | 2 | 3 | 1 | 1 | 1 | 1 |
| Ion Channels (Membrane & Transporters) | potassium M alpha | potassium large conductance calcium-activated | L16912 | 0 | 0 | 0 | 4 | 0 | 0 | 1 | 0 | 1 |
| Ion Channels (Voltage-Gated) | CCHB3 | calcium channel (dihydropyridine-sensitive; L-type) | U20372 | 1 | 1 | 0 | 3 | 2 | 1 | 1 | 1 | 2 |
| Metalloproteinases | MMP14 | matrix metalloproteinase 14 precursor | X83536 | 1 | 2 | 2 | 3 | 2 | 1 | 3 | 1 | 1 |
| Nucleotide Metabolism | PAH | phenylalanine-4-hydroxylase | X51942 | 2 | 1 | 0 | 4 | 1 | 1 | 1 | 1 | 2 |
| Oncogenes & Tumor Suppressors | abl | abl proto-oncogene | L10656 | 1 | 2 | 0 | 2 | 3 | 0 | 1 | 1 | 1 |
| Oncogenes & Tumor Suppressors | R-ras | R-ras protein | M21019 | 1 | 1 | 1 | 6 | 2 | 0 | 1 | 0 | 2 |
| Oncogenes & Tumor Suppressors | Lfc | Lfc proto-oncogene | U28495 | 1 | 1 | 0 | 3 | 1 | 0 | 1 | 0 | 1 |
| Oncogenes & Tumor Suppressors | EB1 | EB1 APC-binding protein | U51196 | 1 | 1 | 0 | 3 | 2 | 1 | 1 | 1 | 1 |
| Oncogenes & Tumor Suppressors | Met | Met proto-oncogene | Y00671 | 1 | 1 | 1 | 5 | 2 | 0 | 2 | 1 | 2 |
| Oncogenes & Tumor Suppressors | c-Mpl | thrombopoietin receptor | Z22649 | 2 | 3 | 1 | 4 | 2 | 1 | 2 | 2 | 2 |
| Proteosomal Proteins | Macropain | Proeasome Component C8 | AF055983 | 1 | 1 | 1 | 5 | 2 | 1 | 2 | 1 | 2 |
| Recombination Proteins | RAG2 | V(D)J recombination activating protein | M64796 | 1 | 1 | 0 | 3 | 3 | 1 | 2 | 1 | 2 |
| Serine Proteases | EC 3.4.21.7 | Plasminogen Precursor (EC 3.4.21.7) | J04766 | 1 | 0 | 0 | 4 | 1 | 1 | 2 | 2 | 2 |
| Stress Response Proteins | EI24 | etoposide induced p53 responsive | U41751 | 0 | 2 | 1 | 1 | 3 | 1 | 1 | 1 | 2 |
| Unclassified Proteins | NGF-inducible protein | NGF-inducible protein TIS21 | M64292 | 3 | 2 | 1 | 3 | 2 | 1 | 2 | 1 | 1 |
| Unclassified Proteins | EC 3.1.3.48 | Putative tyrosine phosphatase | U92437 | 1 | 1 | 1 | 4 | 2 | 1 | 2 | 0 | 1 |
Ratio of Gene Expression (Treatment/Saline) was calculated from individual expressions as % of beta-actin.
Numbers in bold indicate peak of gene expression.