Table 3.
Genes Overexpressed in Prostate Cancer
| Accession no.* | Description | Fold change average† | Location of high gene expression‡ | Normal average§ | Cancer average§ | P¶ |
|---|---|---|---|---|---|---|
| X94323 | Specific granule protein (SGP28) | 21.1 | Tumor epithelium | 61 | 1277 | 0.0265 |
| Z98744 | H2A histone family, member D | 10.4 | Tumor epithelium | 346 | 3606 | 0.0012 |
| S82986 | Homeo box C6 | 8.0 | Tumor epithelium | 139 | 1116 | 0.0172 |
| AJ130733 | Alpha-methylacyl-CoA racemase | 6.2 | Tumor epithelium | 1153 | 7132 | 0.0060 |
| U24577 | LDL-phospholipase A2, group VII | 6.2 | Tumor epithelium | 369 | 2281 | 0.0112 |
| AB017430 | Kinesin-like DNA binding protein (KNSL4) | 5.6 | n.s.d. | 275 | 1549 | 0.0033 |
| AD001528 | Spermine synthase | 5.6 | n.s.d. | 1364 | 7628 | 0.0087 |
| X07732 | Hepsin | 5.3 | Tumor epithelium | 2344 | 12315 | <0.0001 |
| AI039144 | H2A histone family, member A | 5.2 | Tumor epithelium | 832 | 4308 | 0.0007 |
| AF007149 | Clone | 5.0 | Tumor epithelium | 383 | 1924 | 0.0091 |
| U80456 | Transcription factor SIM2 | 5.0 | Tumor epithelium | 379 | 1898 | 0.0286 |
| AL049977 | Claudin 8 | 4.7 | Tumor epithelium | 891 | 4207 | 0.0013 |
| M77836 | Pyrroline 5-carboxylate reductase 1 | 4.4 | Tumor epithelium | 733 | 3244 | 0.0001 |
| U83660 | Multidrug resistance-associated protein (MRP4) | 4.4 | Tumor epithelium | 270 | 1175 | 0.0456 |
| AL049977 | Claudin 8 | 4.3 | Tumor epithelium | 390 | 1665 | 0.0078 |
| AB002387 | Myosin VI | 4.2 | Tumor epithelium | 351 | 1482 | 0.0024 |
| AF071202 | ABC transporter MOAT-B | 4.1 | Tumor epithelium | 470 | 1922 | 0.0237 |
| X92689 | GalNac-T3 | 3.9 | Tumor epithelium | 295 | 1155 | 0.0362 |
| AF052107 | Clone | 3.9 | n.s.d. | 1158 | 4526 | 0.0001 |
| M99487 | Prostate-specific membrane antigen 1 (PSMA) | 3.9 | Tumor epithelium | 2867 | 11194 | 0.0219 |
| AI936759 | Clathrin coat associated protein AP19 | 3.8 | Tumor epithelium | 330 | 1255 | 0.0039 |
| X00088 | H2B histone family, member R | 3.8 | Tumor epithelium | 307 | 1164 | 0.0224 |
| AI189287 | H1 histone family, member 2 | 3.8 | Tumor epithelium | 599 | 2247 | 0.0024 |
| AF007216 | Sodium bicarbonate cotransporter (HNBC1) | 3.7 | Tumor epithelium | 1802 | 6656 | 0.0018 |
| AA290994 | Clone | 3.7 | n.s.d. | 446 | 1649 | 0.0383 |
| D82345 | NB thymosin beta | 3.6 | Tumor epithelium | 2317 | 8232 | <0.0001 |
| AL080199 | Clone | 3.4 | Tumor epithelium | 385 | 1327 | 0.0028 |
| M95610 | Alpha 2 type IX collagen (COL9A2) | 3.3 | Tumor epithelium | 459 | 1495 | 0.0113 |
| L08044 | Human intestinal trefoil factor 3 | 3.2 | Tumor epithelium | 3807 | 12338 | 0.0469 |
| AL049764 | Peroxisomal membrane protein (PMP34) | 3.2 | n.s.d. | 337 | 1092 | 0.0001 |
| AL079298 | Methylcrotonoyl-CoA carboxylase 2 | 3.2 | Tumor epithelium | 545 | 1733 | 0.0243 |
| AI620381 | MGC3077 | 3.1 | n.s.d. | 3711 | 11604 | 0.0004 |
| AL049969 | Clone | 3.1 | n.s.d. | 5865 | 18178 | 0.0008 |
| M30894 | T-cell receptor gamma locus | 3.1 | Tumor epithelium | 6539 | 19975 | <0.0001 |
| AI935146 | GalNac-T3 | 3.0 | Tumor epithelium | 592 | 1775 | 0.0015 |
| Y10183 | Activated leukocyte-cell adhesion molecule | 3.0 | Tumor epithelium | 2182 | 6494 | 0.0026 |
| M99487 | Prostate-specific membrane antigen 1 (PSMA) | 2.9 | Tumor epithelium | 2504 | 7307 | 0.0230 |
| X87176 | 17-Beta-hydroxysteroid dehydrogenase 4 | 2.9 | n.s.d. | 1908 | 5557 | 0.0083 |
| AF045229 | Regulator of G protein signaling 10 (RGS10) | 2.9 | n.s.d. | 405 | 1165 | 0.0001 |
| AF035315 | Clone | 2.9 | Tumor epithelium | 2523 | 7194 | 0.0002 |
| AB011004 | UDP-N-acetylglucosamine pyrophosphorylase | 2.8 | n.s.d. | 1058 | 2984 | <0.0001 |
| D87682 | KIAA0241 | 2.8 | n.s.d. | 395 | 1108 | 0.0001 |
| U51903 | RasGAP-related protein (IQGAP2) | 2.8 | Tumor epithelium | 965 | 2699 | 0.0004 |
| AC005053 | STEAP | 2.8 | Tumor epithelium | 5785 | 16147 | 0.0001 |
| AI885852 | H2A histone family, member O | 2.8 | Tumor epithelium | 8332 | 23201 | 0.0006 |
| AI570572 | Ras-related C3 botulinum toxin substrate 3 | 2.8 | n.s.d. | 590 | 1636 | 0.0050 |
| AB017563 | Immunoglobulin superfamily, member 4 | 2.7 | Tumor epithelium | 1249 | 3417 | 0.0499 |
| Z80780 | H2B histone family, member H | 2.7 | Tumor epithelium | 893 | 2429 | 0.0096 |
| M68840 | Monoamine oxidase A (MAO A) | 2.7 | n.s.d. | 2421 | 6555 | 0.0065 |
| AL109672 | Integral type I protein | 2.7 | Tumor epithelium | 3681 | 9922 | 0.0019 |
| AL049933 | G protein, alpha-1 subunit | 2.7 | n.s.d. | 564 | 1496 | <0.0001 |
| X73424 | Propionyl-CoA carboxylase a subunit | 2.6 | n.s.d. | 822 | 2170 | 0.0005 |
| AC002073 | LIM domain kinase 2 | 2.6 | Tumor epithelium | 826 | 2173 | <0.0001 |
| Z80776 | H2A histone family, member G | 2.6 | Tumor epithelium | 2525 | 6627 | 0.0015 |
| L41816 | Cam kinase I | 2.6 | n.s.d. | 633 | 1650 | 0.0243 |
| AI200373 | H2A histone family, member I | 2.6 | Tumor epithelium | 938 | 2439 | 0.0032 |
| M93036 | Carcinoma-associated antigen GA733-2 | 2.6 | Tumor epithelium | 2741 | 7010 | <0.0001 |
| AL080181 | Immunoglobulin superfamily, member 4 | 2.6 | n.s.d. | 2053 | 5236 | 0.0087 |
| AB018330 | CAM kinase kinase 2, beta | 2.5 | Tumor epithelium | 2710 | 6900 | 0.0023 |
| L10333 | Reticulon 1 | 2.5 | Tumor epithelium | 412 | 1040 | 0.0065 |
| AF002668 | Fatty acid desaturase MLD | 2.5 | n.s.d. | 4574 | 11501 | 0.0018 |
| AL009179 | H2B histone family, member C | 2.5 | Tumor epithelium | 1004 | 2522 | 0.0086 |
| AC004381 | Clone | 2.5 | Tumor epithelium | 681 | 1710 | 0.0468 |
*GenBank accession number.
†Fold change represents mRNAs differentially up-regulated in carcinoma relative to adjacent normal tissue.
‡Putative cell-type location of high gene expression as suggested of selected microdissected material. Only fold differences >4 between gene expression in tumor epithelium and tumor stroma were taken into consideration.
§Average, average difference = expression intensity calculated by Affymetrix software.
¶P value was calculated by the Student’s t-test.
n.s.d., no significant difference, i.e. fold difference between gene expression in tumor epithelium and tumor stroma <4.
Some genes are represented by several sequences on the microarray, e.g. Claudin 8, GalNac-T3, PSMA.