Table 2.
Induction of IBD in IL-10-KO Mice by E. faecalis
| Group | Weeks colonized* | No. of mice† | No. of mice with IBD histopathology‡ | ||
|---|---|---|---|---|---|
| Cecum | Colon | Rectum | |||
| I Early (5 to 15 weeks) | 5 | 3 | 0 | 0 | 1 |
| 7 | 1 | 1 | 0 | 1 | |
| 10 | 10 | 0 | 8 | 9 | |
| 12.5 | 1 | 1 | 1 | 1 | |
| 15 | 4 | 1 | 2 | 4 | |
| II Late (20 to 28 weeks) | 20 | 5 | 4 | 4 | 5 |
| 21 | 4 | 4 | 4 | 4 | |
| 24 | 3 | 3 | 3 | 3 | |
| 28 | 4 | 3 | 4 | 3 | |
| Colonized with E. faecalis from birth | 25 | 5 | 1 | 0 | 5 |
*Indicates length of time mice were colonized by E. faecalis. Mice were colonized at 7 to 17 weeks of age, except those colonized at birth.
†Number of mice colonized with E. faecalis.
‡Number of mice with IBD.