Table 1.
Summary of Parameters Used to Assess the Intestinal Radiation Response (Median and Interquartile Range for Each Parameter, Experimental Group, and Time Point after the End of Irradiation)
| Sham-irradiated | 4.2 Gy × 8 | 4.2 Gy × 16 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 Day | 2 Weeks | 6 Weeks | 26 Weeks | 1 Day | 2 Weeks | 6 Weeks | 26 Weeks | 1 Day | 2 Weeks | 6 Weeks | 26 Weeks | |
| RIS | 0 (0–1) | 0 (0–0) | 0 (0–1.5) | 0 (0–0) | 3 (2–3) | 2 (0–2) | 1 (1–1) | 0 (0–.75) | 3 (3–5.25) | 3 (.75–5.25) | 6 (5–8.5) | 5 (2–15) |
| MSA | 2.1 (2.0–2.2) | 2.4 (2.3–2.5) | 2.1 (2.1–2.2) | 1.9 (1.8–2.0) | 1.5 (1.1–1.7) | 1.6 (1.5–1.9) | 1.5 (1.5–1.6) | 1.7 (1.6–1.8) | 1.3 (.9–1.5) | 1.5 (1.5–1.7) | 1.0 (.8–1.2) | 1.5 (1.0–1.6) |
| IWT | 168 (151–238) | 107 (105–120) | 136 (128–158) | 142 (98–167) | 210 (173–289) | 301 (290–409) | 241 (232–329) | 219 (204–228) | 380 (288–470) | 354 (282–850) | 758 (605–953) | 524 (407–868) |
| MPO | 48 (36–57) | 30 (21–60) | 57 (43–69) | 73 (36–97) | 34 (34–63) | 29 (27–36) | 51 (25–194) | 70 (25–121) | 119 (38–367) | 177 (56–530) | 689 (517–861) | 130 (107–324) |
| Coll1 | 13033 (12324–24180) | 19366 (11422–29477) | 22355 (9810–34425) | 13290 (12270–30719) | 19203 (6349–40328) | 50035 (16355–70118) | 42405 (12372–95459) | 51427 (21679–63382) | 41021 (29589–49586) | 54682 (35467–78936) | 58854 (31666–101304) | 40549 (18297–78643) |
| Coll3 | 35377 (30854–36847) | 37430 (32465–40563) | 46152 (34324–48462) | 27152 (25133–39907) | 58941 (46619–73652) | 79330 (74933–83066) | 102102 (94509–120522) | 73739 (44644–123463) | 62847 (53136–89131) | 110090 (83369–136503) | 99660 (60159–141901) | 100986 (75774–132601) |
| TGF-β | 1807 (509–2625) | 291 (165–344) | 1213 (329–1468) | 638 (448–1158) | 37642 (10530–64856) | 9660 (7696–17017) | 7930 (4840–17451) | 5525 (165–31131) | 45753 (42691–88022) | 11935 (7999–46397) | 65667 (24016–116803) | 66856 (1496–185198) |
RIS, radiation injury score; MSA, mucosal surface area (cm2/cm3); IWT, intestinal wall thickness (μm); MPO, number of myeloperoxidase-positive cells per 10 ×40 fields; Coll1, collagen I (μm2); Coll3-collagen III (μm2); TGF-β, extracellular matrix-associated transforming growth factor-β (μm2). See text for further explanation of individual parameters. All parameters exhibit highly statistically significant radiation dose-dependent changes.