Figure 3.
Cardiac dSUR function protects heart performance against electrical pacing. Heart failure rate after 30-second high frequency (6Hz) external pacing in one-week old RNAi-mediated knockdown mutants (progeny of UAS-dSUR-RNAi flies with the heart-specific GMH5 driver. Controls (progeny of GMH5 crossed with yw and yw crossed with UAS-dSUR-RNAi lines) show a low rate of heart failure. Conversely, cardiac dSUR knockdown results in significantly elevated levels of pacing-induced heart failure (*<0.01). Adapted from Akasaka et al. (2006).