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Representative proliferative foci from DEN-injected mice. TGF-α/Bcl-2 double (A), and TGF-α single (B) transgenic mice, both at 5 months. Proliferative hepatocytes were detected by BrdU incorporation and immunohistochemistry. Note the smaller focus size and fewer number of BrdU-positive hepatocytes in the TGF-α/Bcl-2 double transgenic mouse. Magnification, ×100.
