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. 2002 May;160(5):1561–1565. doi: 10.1016/S0002-9440(10)61102-9

Figure 3.

Figure 3.

Histamine production by SCLC cell lines. A: Histamine release by SCLC cells (H69) with time in culture in RPMI-1640 containing 97 μmol/L histidine. B: Cell contents and histamine in supernatants after 48 hours in culture were enhanced by increasing the substrate concentration. C: Histamine in cells and supernatants was also determined in cells cultivated without serum. Experiments in F12-DMEM medium containing 194 μmol/L histidine and after further addition of 500 μmol/L histidine (+), are shown. Under both conditions histamine in cells and supernatants increased. Values are means of four experiments ± SD.