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Perforin/granzyme-mediated (4-hour incubation with autologous B-LCL as target cells) and Fas/FasL-mediated cytotoxicity (18-hour incubation with Fas+ L-1210 mouse lymphoblasts as target cells) of drug-specific CD4+ TCCs (open symbols) or of drug-specific CD8+ TCLs (filled symbols) from patients AP and JS. Experiments were done in duplicate or triplicate cultures and SEM was calculated.
