Alignment of thrombomodulin genes sequenced to date in the region of interest. Squirrel monkey, rhesus monkey, and chimpanzee thrombomodulin genes are virtually identical to human, including at Met388, and are not shown. Methionine 388 is indicated in bold and is conserved. Note the conservation of phenylalanine 376 as described in the text as well as the cysteines, involved in disulfide bonds, and of asparagine 391, which has been shown to be glycosylated in humans.